Posted: February 20th, 2022
Leg ulcers (LUs) do indeed have a negative impact on patients’ lives and jobs, but they also impose a significant economic burden on society. Larval therapy, a potentially underutilized biological debridement method, aids in treating LUs. Our research aims to see if larval therapy can help patients with LUs. Electronic databases will be searched for PubMed, China National Knowledge Infrastructure Database, the Cochrane Library, Wanfang Database, EMBASE, Web of Science, and Chinese Biological Medicine. Randomized and Clinical studies are welcome to apply. There will be no language barriers, and the quest will go until June 2020. The significant outcomes assessed were the rate of complete healing following therapy, time to ulcer healing, wound surface area reduction, and adverse effects. Risk ratios will be employed for categorical data, and for measurement data, the weighted mean difference will be used. If there is variability, subgroup analysis, and sensitivity analysis will be considered. The narrative summary and quantitative analysis of the data synthesis results will be carried out. The ethics committee does not need to approve this systematic review because no specific patient data is gathered. The findings of the research will be published in peer-reviewed journals
Leg ulcers (LUs) are difficult-to-recover lesions on the foot or leg that originate below the knee (SIGN, 2009). Ulcers are caused by various factors, which are chronic venous inadequacy in the lower limbs, peripheral artery disease, and diabetes (Mekkes et al., 2003). The condition has become a significant public health concern around the continent. Diabetic foot ulcers affect between 10% and 25% of the population with diabetes, according to estimates (DFUs). By 2030, more than 50 million people will have DFUs (Armstrong et al., 2014). According to epidemiological research, 0.1 percent to 0.3 percent of people in Great Britain and Northern Ireland in the UK have venous leg ulcers (VLUs) at any given moment. Treatment of venous LUs has predicted cost is around £ 400 million in the UK. One us dollar billion in the United States per year (Alavi et al., 2014) LUs significantly impact patients’ sleep and interpersonal relationships, lowering their worth of life and causing significant financial losses for patients and a high cost to the health service.
Larvae develop on necrotic tissue, cell components, and fluid in the wound, effectively devitalizing it. Researchers found that regular debridement resulted in much greater wound healing in several randomized controlled clinical trials, regardless of topical treatments. Debridement is a vital part of wound care, and it’s just as crucial as pressure reduction when it comes to promoting wound healing. Larvae feed on cellular debris, necrotic tissue, and pus or fluids in the wound, effectively devitalizing it. Researchers found that regular debridement resulted in much greater wound healing in several randomized controlled clinical trials, regardless of topical treatments. Debridement is a vital part of wound care, and it’s just as crucial as pressure reduction when it comes to promoting wound healing (Anderson, 2006).
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