Posted: February 15th, 2022
The Department of Health, Education, and Welfare (DHEW) charged the Tuskegee Syphilis Project Ad Hoc Advisory Panel in 1972 with evaluating the study and assessing whether the study was justifiable in 1932 and whether it should have been continued once penicillin became widely accessible. Although this history is well documented, the Advisory Panel report gives source documents to analyze and appraise the defenders’ arguments, most recently through the work of Reverby. Furthermore, the Panel issued its report close to the time the study was made public, so if identity politics corrupted the probe, it should have been evident in that report.
The evidence used by the Panel for the risk to human life without treatment came from Moore et al. Cooperative .’s Clinical Studies reports. According to the Panel, “as early as 1932, it was recognized that 85 percent of patients treated in late latent syphilis [with arsenic and bismuth compounds (metal therapy)] would enjoy lengthy preservation of good health and escape from disease, as opposed to 35 per cent left untreated.” It quoted Tuskegee Study results demonstrating that the group with untreated syphilis had morbidity much above that of the non-syphilitic control group. The Panel cited Wenger’s testimony from a seminar in 1950: “We now know, where we could only assume previously, that we have contributed to their ailments and shortened their lives.”
By the early 1950s, the Panel reported, the therapeutic effects of penicillin for late and latent syphilis had been clinically documented. In 1953, the USPHS recommended therapy for syphilitic mothers at all stages of infection, and in 1960, penicillin was shown to be the most effective treatment for neurosyphilis. 14 There was no evidence that Tuskegee study participants were given the option of penicillin medication once it became widely available.
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